SURFACE MODIFIED TITANIUM DIOXIDE/POLY(LACTIC ACID) NANOCOMPOSITE FILMS FOR TISSUE ENGINEERING
نویسندگان
چکیده
Objective
 This study aims to synthesize and characterize the
 nanocomposite films incorporating unmodified and
 modified nanoparticles within the poly(lactic acid)
 matrix, investigate their usage as an alternative
 scaffold for tissue engineering.
 Materials Methods
 Titanium dioxide (TiO2) were firstly
 grafted by L-lactic acid oligomer (LA-g-TiO2) mixture of propionic acid/hexylamine (AA-g-TiO2),
 respectively. Then modified
 incorporated poly(lactic
 acid) matrix via solvent casting method produce
 PLA/TiO2, PLA/LA-g-TiO2, PLA/AA-g-TiO2
 films. The chemical, thermal mechanical structures these synthesized were
 subsequently characterized.
 Results
 attenuated total reflectance (ATR) results
 demonstrated that surface modification was accomplished. results of
 differential scanning calorimeter (DSC) analysis
 showed crystallization PLA was
 partly increased incorporation nanoparticles. thermogravimetric
 analysis (TGA) addition LA-g-TiO2
 into polymer improved stability
 PLA/LA-g-TiO2 film more than AA-g-TiO2 matrix. The
 first second decomposition temperatures nanocomposites containing LA-g-TiO2 348.3 oC
 392 oC, respectively, which 6% greater than
 those neat PLA. micrograph atomic force
 microscopy (AFM) indicated
 homogeneously
 dispersed in matrices. dynamic
 (DMA) most efficient bonding compatibility obtained
 compared other nanocomposites.
 Conclusion
 These nanoparticles, AA-g-
 TiO2, enhanced properties
 owing uniform
 distribution good interactions with polymeric Therefore, nanocomposites
 can be utilized alternative scaffolds bone tissue
 engineering.
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ژورنال
عنوان ژورنال: Süleyman Demirel Üniversitesi T?p Fakültesi dergisi
سال: 2022
ISSN: ['1300-7416', '2602-2109']
DOI: https://doi.org/10.17343/sdutfd.1016353